Menarini A-Ret Tretinoin 0.05% Gel is a form of vitamin A that is used to treat acne which appears as spots or pimples on your face, chest, or back. It also helps to smooth rough facial skin and to reduce fine wrinkles on the skin. A-Ret Tretinoin 0.05% Gel reduces excessive oil production of the skin. Ideally, a pinpoint application at nighttime is recommended for the duration prescribed by your doctor. The amount you need and for how long you need to take it will depend on what you are being treated for. You should normally wash and dry the affected area before applying a thin layer of this medicine. Follow your doctor’s instructions. You should not apply it to damaged or broken skin and avoid contact with your mouth, eyes, and nose.